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Why Your GC Inlet Total Flow Drops During a Temperature Ramp — And How to Fix It  

Why Your GC Inlet Total Flow Drops During a Temperature Ramp — And How to Fix It  

by Lee Polite | Dec 8, 2025

Understanding constant pressure vs. constant flow in gas chromatography. Gas chromatography is incredibly powerful, but like any technique, the instrument will occasionally behave in ways that make you stop and ask, “Wait… is that supposed to happen?” One common...
Understanding the Master Resolution Equation: Your Key To Easier Method Development & Troubleshooting  

Understanding the Master Resolution Equation: Your Key To Easier Method Development & Troubleshooting  

by Lee Polite | May 22, 2025

For any chromatographer, whether seasoned or just starting, the ultimate goal is to achieve good separation between analytes. This separation, known as resolution (Rs), is not a matter of chance but can be understood and manipulated through a fundamental relationship...
3 Essential Gas Generators for Gas Chromatography (GC) Explained  – Hydrogen, Air & Nitrogen Generators.

3 Essential Gas Generators for Gas Chromatography (GC) Explained  – Hydrogen, Air & Nitrogen Generators.

by Lee Polite | May 19, 2025

Gas chromatography (GC) relies on a steady and reliable supply of gases, making gas generators an essential component of a well-functioning GC system. Modern laboratories are increasingly adopting gas generators instead of traditional gas cylinders to enhance...
GC Sample Prep Essentials: Nailing Solvents, Dilution & Injection 

GC Sample Prep Essentials: Nailing Solvents, Dilution & Injection 

by Lee Polite | Apr 22, 2025

When you’re working with Gas Chromatography (GC), one of the most critical steps is getting the sample into the GC. You might already understand gas flow paths and general instrument operation—but none of that matters if your sample isn’t prepared correctly. So,...
Pyrolysis GC: How to Analyze Paint, Plastics, and Polymers with Gas Chromatography  

Pyrolysis GC: How to Analyze Paint, Plastics, and Polymers with Gas Chromatography  

by Lee Polite | Apr 22, 2025

When you’re running a Gas Chromatograph (GC), one of the most important steps is getting the sample into the instrument. In a previous video, I talked about common autosamplers—like using 2 mL vials with a liquid autosampler, or 20 mL vials for headspace...
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